Due to the complex structure and the microscopic inhomogeneity of polysaccharides, the synthesis of polysaccharides has long plagued synthetic chemists. CD BioGlyco can provide customers with a custom one-stop polysaccharide synthesis service, According to their research needs, customers can obtain different types and modified polysaccharides. We have confidence to be your essential research assistant in the field of glycobiology.

Background

Polysaccharides are the most abundant biopolymers on earth. They can perform various structural and regulatory functions. Their biological activity depends on the chemical structure, including the composition of monosaccharides, linkages below sugar residues, and the solution conformation. In contrast to polypeptides and polynucleotides, polysaccharides are branched, and each glycosidic bond can form a new stereocenter, which allows only a few monosaccharides to form a variety of different polymers. The construction of polysaccharides through chemical, enzymatic or chemoenzymatic synthesis requires stereo and regional control at each step. For carbohydrates separated as heterogeneous mixtures, synthesis still faces difficulties in detailed molecular understanding.

Due to the important biological functions of polysaccharides, learning the comprehensive definition of their linearity and branching is essential. Many researchers have reported that the chemical modification of polysaccharides significantly increases the diversity of structures, improves biological activity, and even adds new biological activities, including antioxidant and anti-tumor properties, as well as anticoagulant and immunomodulatory activities.

Services

CD BioGlyco uses the following methods to synthesize polysaccharides.

• We combine other technologies on the solid-based automated glycan assembly (AGA) to obtain 100-mers polysaccharides. This method not only ensures high coupling efficiency, but also minimizes the cycle time.
• Our customized modifications include sulfation, phosphorylation, carboxymethylation, selenization, methylation, acetylation, and other chemical modifications. And many polysaccharides with different labels, such as biotin, fluorescein and rhodamine, etc.

Advantages of Us

• Customized route design
• Outstanding process development, optimization and scale-up
• Able to synthesize different types of polysaccharides
• Effective multi-step synthesis

CD BioGlyco has numerous successful experiences in the custom synthesis of polysaccharides. Our well-trained researchers and the most advanced facilities can provide customers with higher-quality synthesis services to help customers explore polysaccharides faster and more comprehensively.

Customers can contact our employees directly and we will respond promptly. If you are interested in our services, please contact us for more detailed information.

References:

1. Joseph, A.A.; et al. Total synthesis of polysaccharides by automated glycan assembly. J. Am. Chem. Soc. 2020, 142: 8561-8564.
2. Xu, Y.; et al. Chemically modified polysaccharides: synthesis, characterization, structure activity relationships of action. International Journal of Biological Macromolecule. 2019, 132: 970-977.