The synthesis of sialyl tumor antigen-peptides is of great significance for cancer diagnosis and treatment. CD BioGlyco provides our clients with high-quality sialyl tumor antigen-peptides production service by using a variety of synthesis techniques.
Aberrant glycosylation of cell surface glycoproteins is a common feature of numerous tumor cell types. These, often truncated carbohydrate structures, are called tumor-associated carbohydrate antigens (TACAs). In cancer, the expression of mucins is increased, and their carbohydrate side chains are altered due to incomplete glycosylation and early sialylation as is shown by several immunohistochemical studies. Four common TACAs include N-acetylgalactosamine (GalNAc) and Gal-1,3-GalNAc, commonly termed the Tn and T antigens, as well as the sialylated antigens, sialyl Tn and 2,6-sialyl T. Glycopeptides, containing partial structures of cancer-associated cell-surface glycoproteins, are considered promising candidates for the construction of tumor-selective immunostimulating antigens. The carbohydrate part of the glycopeptide is important for producing a cellular as well as a humoral immune response. Therefore, it is of interest to synthesize sialyl tumor antigen-peptides and apply them as the epitopes in cancer research. For the construction of immunostimulating antigens, glycopeptide partial structures of mucins MUC1 and MUC4 with tumor-associated sialyl-Tn, α2,6-sialyl-T, and α2,3-sialyl-T antigens have been synthesized.
Fig.1 Structures of TACAs. (Corcilius, 2013)
CD BioGlyco provides custom sialyl tumor antigen-peptides production services, including but not limited to:
Large amounts of sialyl-Tn antigen-containing peptides are prepared from the activase E digests by the combination of gel filtration and hydrophilic partitioning.
We stereoselectively synthesize sialyl tumor-associated carbohydrate antigen-derived amino acids from an oxazolidinone-derived sialoside donor. These glycosylamino acids are employed directly in the solid-phase synthesis of glycopeptides. In the process, we use an oxazolidinone to direct auxiliary in the stereoselective synthesis of glycosylamino acids bearing the Sialyl-Tn and Sialyl-T antigens, as well as their rapid and efficient incorporation into complex glycopeptides.
We also provide the solid-phase synthesis of the sialyl Tn glycopeptide fragment of HIV gp 120.
CD BioGlyco is the most reliable partner for Sialic Acid Analysis with lots of experienced scientists. We produce sialyl tumor antigen-peptides with high stereoselectivity. If you need any further information, please feel free to contact us.
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