CXCR antagonist SCH-527123, Purity ≥98%

Synonym: Navarixin; 473727-83-2; SCH 527123; SCH-527123; Sch527123; (R)-2-Hydroxy-N,N-dimethyl-3-((2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)benzamide; CXCR antagonist

CAS Number: 473727-83-2
Compound CID: 9865554

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SCH-527123, soluble in DMSO and ethanol and insoluble in water, is an active CXCR antagonist. It targets 125I-CXCL8-CXCR1, 125I-CXCL8-CXCR2, Cynomolgus CXCR1, Cynomolgus CXCR2, mouse CXCR2, and rat CXCR2.

Molecular Weight

397.42

Molecular Formula

C₂₁H₂₃N₃O₅

Targets

125I-CXCL8-CXCR1: 43 nM; 125I-CXCL8-CXCR2: 0.97 nM; Cynomolgus CXCR1: 41 nM (Kd); Cynomolgus CXCR2: 0.08 nM (Kd); Mouse CXCR2: 0.2 nM (Kd); Rat CXCR2: 0.2 nM (Kd)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 71 mg/mL (178.65 mM); Water: Insoluble; Ethanol: 71 mg/mL (178.65 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

SCH-527123 can be used to investigate the inhibition of chemokine receptors CXCR1 and CXCR2 in inflammation.

Storage

Store at -20ºC.