CXCR inhibitor AMG 487, Purity ≥98%

Synonym: AMG 487; 473719-41-4; AMG-487; 355CGR2CBL; CHEMBL397983; (R)-N-(1-(3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(pyridin-3-ylmethyl)-2-(4-(trifluoromethoxy)phenyl)acetamide; CXCR inhibitor

CAS Number: 473719-41-4
Compound CID: 24957182

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AMG 487, soluble in DMSO and ethanol and insoluble in water, targets the chemokine receptors CXCR, which are part of the GPCR family. It targets 125I-IP10-CXCR3 and 125I-ITAC-CXCR3.

Molecular Weight

603.59

Molecular Formula

C₃₂H₂₈F₃N₅O₄

Targets

125I-IP10-CXCR3: 8 nM; 125I-ITAC-CXCR3: 8.2 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 97 mg/mL (160.7 mM); Water: Insoluble; Ethanol: 97 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

AMG 487 is a CXCR3 antagonist used to study its role in immune cell trafficking and inflammatory diseases.

Storage

Store at -20ºC.