Properties
Description
Balicatib, soluble in DMSO and ethanol and insoluble in water, obstructs cysteine proteases, enzymes implicated in numerous diseases due to their role in protein degradation. It targets cathepsin B, cathepsin K, cathepsin L, and cathepsin S.
Molecular Formula
C23H33N5O2
Targets
Cathepsin B: 61 nM; cathepsin K: 22 nM; cathepsin L: 48 nM; Cathepsin S: 2900 nM
Solubility
DMSO: 72 mg/mL (174.95 mM); Water: Insoluble; Ethanol: 3 mg/mL (7.28 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
Balicatib is used to research its effect on cysteine proteases, particularly cathepsins, in osteoclast-related bone diseases.
