Properties
Description
Calpeptin, soluble in DMSO and ethanol and insoluble in water, obstructs cysteine proteases, enzymes implicated in numerous diseases due to their role in protein degradation. It targets Calpain I (human platelets), Calpain I (porcine erythrocytes), Calpain II (porcine kidney), and papainb.
Molecular Formula
C20H30N2O4
Targets
Calpain I (human platelets): 40 nM (ID50); Calpain I (porcine erythrocytes): 52 nM (ID50); Calpain II (porcine kidney): 34 nM (ID50); Papainb: 138 nM (ID50)
Solubility
DMSO: 66 mg/mL (182.09 mM); Water: Insoluble; Ethanol: 66 mg/mL (182.09 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
Calpeptin is utilized to inhibit calpain, aiding the investigation into cellular processes like signal transduction, proliferation, and apoptosis.
