Cytochrome P450 inhibitor, Avasimibe, Purity ≥98%

Synonym: 166518-60-1; CI-1011; CI1011; PD 148515; [2,6-Di(propan-2-yl)phenyl] N-[2-[2,4,6-tri(propan-2-yl)phenyl]acetyl]sulfamate

MDL: MFCD00934956
CAS Number: 166518-60-1
Compound CID: 166558

Product Size

10 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Avasimibe, soluble in DMSO and ethanol and insoluble in water, is an effective cell metabolism inhibitor, that has the ability to prevent the pathway of metabolism by inhibiting cytochrome P450. It targets the ACAT, CYP1A2, CYP2C19, and CYP2C9.

Molecular Weight

501.7

Molecular Formula

C₂₉H₄₃NO₄S

Targets

ACAT: 3.3 μM; CYP1A2: 13.9 μM; CYP2C19: 26.5 μM; CYP2C9: 2.9 μM

Form

Lyophilized powder

Purity

≥98%

Titer

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects

Solubility

In vitro: DMSO: 96 mg/mL (191.34 mM); Water: insoluble; Ethanol: 8 mg/mL (15.94 mM); In vivo: 2% DMSO + corn oil, 4 mg/mL

Applications

Avasimibe is a metabolism inhibitor that can be studied extensively for its potential therapeutic applications in the treatment of conditions like atherosclerosis.