Properties
Description
Cobicistat, soluble in DMSO and ethanol and insoluble in water, is an effective cell metabolism inhibitor, that has the ability to prevent the pathway of metabolism by inhibiting cytochrome P450. It targets the CYP3A.
Molecular Formula
C40H53N7O5S2
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Solubility
In vitro: DMSO: 85 mg/mL (109.53 mM); Water: insoluble; Ethanol: 85 mg/mL (109.53 mM); In vivo: 5% DMSO + 40% PEG 300 + ddH2O, 9 mg/mL
Stability
In its lyophilized form, the chemical remains stable for 36 months.
Quality Level
Research grade
Applications
Cobicistat is a metabolism inhibitor that can be used for its ability to increase the plasma levels of co-administered antiretroviral drugs, improving their effectiveness and reducing the frequency of dosing.
Storage
Store at -20ºC, and keep desiccated.
