Properties
Description
Ketoconazole, soluble in warmed DMSO and ethanol and insoluble in water, is an effective cell metabolism inhibitor, that has the ability to prevent the pathway of metabolism by inhibiting cytochrome P450. It targets the cyclosporine oxidase and testosterone 6 beta-hydroxylase.
Molecular Formula
C26H28Cl2N4O4
Targets
Cyclosporine oxidase: 0.19 mM; Testosterone 6 beta-hydroxylase: 0.22 mM
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Solubility
In vitro: DMSO (warmed): 5 mg/mL (9.4 mM); Water: insoluble; Ethanol: 7 mg/mL; In vivo: 30% propylene glycol, 5% Tween 80, 65% D5W, 28 mg/mL
Stability
In its lyophilized form, the chemical remains stable for 36 months.
Quality Level
Research grade
Applications
Ketoconazole is a metabolism inhibitor that can be studied extensively for its potential therapeutic applications in the treatment of fungal infections such as athlete’s foot, ringworm, and candidiasis.
Storage
Store at -20ºC, and keep desiccated.
