Properties
Description
TOK-001, soluble in DMSO and warmed ethanol and insoluble in water, is an effective cell metabolism inhibitor, that has the ability to prevent the pathway of metabolism by inhibiting cytochrome P450. It targets the androgen receptor and CYP17.
Molecular Formula
C26H32N2O
Targets
Androgen Receptor: 384 nM; CYP17: 300 nM
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Solubility
In vitro: DMSO: 21 mg/mL (54.04 mM); Water: insoluble; Ethanol (warmed): 36 mg/mL (92.65 mM); In vivo: 0.5% hydroxyethyl cellulose, 28 mg/mL
Stability
In its lyophilized form, the chemical remains stable for 36 months.
Quality Level
Research grade
Applications
TOK-001 is a metabolism inhibitor that plays a key role in blocking the effects of androgens, which are hormones that drive prostate cancer cell growth.
Storage
Store at -20ºC, and keep desiccated.
