Dehydrogenase inhibitor, AG-120, Purity ≥98%

Synonym: 1448347-49-6; Ivosidenib; Ivosidenib; AG120; Tibsovo; AG120; (2S)-N-[(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide; Dehydrogenase inhibitor

MDL: MFCD29036964
CAS Number: 1448347-49-6
Compound CID: 71657455

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AG-120, soluble in DMSO and ethanol and insoluble in water, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting dehydrogenases. The molecular weight of the compound is 582.96, and its molecular formula is C₂₈H₂₂ClF₃N₆O₃.

Molecular Weight

582.96

Molecular Formula

C₂₈H₂₂ClF₃N₆O₃

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 92 mg/mL (157.81 mM); Water: insoluble; Ethanol: 92 mg/mL (157.81 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

AG-120 can be studied extensively for its potential therapeutic applications in the treatment of gliomas and acute myeloid leukemia (AML).