DHFR inhibitor, Methotrexate, Purity ≥98%

Synonym: 59-05-2; MTX; Amethopterin; Abitrexate; Rheumatrex; Trexall; (2S)-2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid; DHFR inhibitor

MDL: MFCD00150847
CAS Number: 59-05-2
Compound CID: 126941

Product Size

100 mg; 200 mg; 500 mg; 1 g

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Methotrexate, soluble in DMSO and insoluble in water and ethanol, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting DHFR. The molecular weight of the compound is 454.44, and its molecular formula is C₂₀H₂₂N₈O₅.

Molecular Weight

454.44

Molecular Formula

C₂₀H₂₂N₈O₅

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO (warmed): 89 mg/mL (195.84 mM); Water: insoluble; Ethanol: insoluble; In vivo: 2% DMSO + 30% PEG 300 + 5% Tween 80 + ddH₂O, 4 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

Methotrexate can be studied extensively for its potential therapeutic applications in the treatment of various cancers, including leukemia, lymphoma, and solid tumors.