DHFR inhibitor, Pemetrexed disodium, Purity ≥98%

Synonym: 150399-23-8; LY-231514; LY231514; Disodium; (2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate; DHFR inhibitor

CAS Number: 150399-23-8
Compound CID: 135413520

Product Size

10 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Pemetrexed disodium, insoluble in DMSO and ethanol and soluble in water, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting DHFR. The molecular weight of the compound is 471.4, and its molecular formula is C₂₀H₁₉N₅Na₂O₆. It targets the DHFR (Cell-free assay), GARFT (Cell-free assay) and TS (Cell-free assay).

Molecular Weight

471.4

Molecular Formula

C₂₀H₁₉N₅Na₂O₆

Targets

DHFR (Cell-free assay)

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: insoluble; Water: 87 mg/mL (184.56 mM); Ethanol: insoluble; In vivo: Saline, 28 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

Pemetrexed disodium can be studied extensively for its potential therapeutic applications in the treatment of non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma.