DHFR inhibitor, Pemetrexed, Purity ≥98%

Synonym: 137281-23-3; Pemetrexed disodium; Alimta; LY231514; (2S)-2-[[4-[2-(2-Amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; DHFR inhibitor

CAS Number: 137281-23-3
Compound CID: 135410875

Product Size

50 mg; 100 mg; 200 mg; 500 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Pemetrexed, insoluble in DMSO and ethanol and soluble in water, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting DHFR. The molecular weight of the compound is 427.41, and its molecular formula is C₂₀H₂₁N₅O₆.

Molecular Weight

427.41

Molecular Formula

C₂₀H₂₁N₅O₆

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: insoluble; Water (warmed): 93 mg/mL (180.09 mM); Ethanol: insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Pemetrexed plays a key role in inhibiting multiple enzymes involved in folate metabolism, including DHFR, thymidylate synthase, and glycinamide ribonucleotide formyltransferase, thus disrupting DNA synthesis in cancer cells.