DHFR inhibitor, Pralatrexate, Purity ≥98%

Synonym: 146464-95-1; PDX; 10-Propargyl-10-deazaaminopterin; D05589; (2S)-2-[[4-[1-(2,4-Diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioic acid; DHFR inhibitor

MDL: MFCD00920897
CAS Number: 146464-95-1
Compound CID: 148121

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Pralatrexate, soluble in DMSO and insoluble in water and ethanol, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting DHFR. The molecular weight of the compound is 477.47, and its molecular formula is C₂₃H₂₃N₇O₅.

Molecular Weight

477.47

Molecular Formula

C₂₃H₂₃N₇O₅

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 27 mg/mL (56.55 mM); Water: insoluble; Ethanol: insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Pralatrexate plays a key role in inhibiting DHFR and thymidylate synthase, leading to reduced cancer cell proliferation.