Given the important contribution to infant intestinal health, the production of disialyllacto-N-tetraose (DSLNT) is of great value for the research of clinical experiments and infant food formulas. CD BioGlyco has a strong continuous and stable supply capacity, providing you with sufficient DSLNT inventory and strong after-sales support.

The Function of Protecting Intestinal Health for DSLNT

Human milk oligosaccharides (HMOs) can regulate intestinal flora, help brain development, and regulate immunity, which is beneficial to the growth and development of babies. As an important HMO, DSLN helps to enhance the beneficial effects of breastfeeding and plays an important role in the prevention of intestinal diseases. It is a good therapeutic candidate oligosaccharide for clinical applications and preclinical experiments.

Fig.1 The structure of DSLNT. (Yu, et al., 2014)

Anti-inflammatory Activity of DSLNT

Because premature infants have multiple health problems such as immature organs, high vulnerability, susceptibility to infection, inflammation, and so on, the clinical treatment methods for this special population are very limited. Breast milk has certain congenital advantages that can prevent many neonatal diseases, and may also play a protective role in high-risk infants, especially in the field of intestinal digestion, such as necrotizing enterocolitis (NEC), which is one of the most common and serious intestinal diseases of premature infants. According to statistics, in the United States, African-American infants are most often infected with this type of intestinal disease. Many studies have shown that DSLNT plays an important role in reducing the risk of this disease. Studies on the pathophysiology of DSLNT have demonstrated that it can regulate mast cell (MC) homeostasis by regulating MC degranulation/accumulation, contributing to the alleviation of NEC. Concentrations of DSLNT in breast milk can be used as biomarkers to determine whether breastfed infants are at risk for the disease.

DSLNT Production Service at CD BioGlyco

CD BioGlyco provides a variety of advanced Production methods to complete the efficient production of DSLNT. The optimization strategies we supply include but are not limited to the following:

• Selection and identification of suitable enzymes.
  Including glycosyltransferases and the corresponding sugar nucleotide biosynthetic.
• One-pot multienzyme reactions.
  Including glycokinase and nucleotidyltransferase.
• Driving the reaction to completion in the direction of product formation.
  Such as the addition of Inorganic pyrophosphate.

Advantages of Us

• Low-cost production.
• High efficiency and selectivity.
• Rich enzyme resources.
• Green environmental protection.
• Tailor-made for corresponding clinical research.

CD BioGlyco provides clients with timely and accurate one-stop services for DSLNT production. If you are interested in our services, please feel free to contact us.

Reference

1. Yu, H.; et al. Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis. Angewandte Chemie International Edition. 2014, 53(26): 6687-6691.