DNA-PK inhibitor AZD-7648, Purity ≥98%

Synonym: 2230820-11-6; AZD7648; AZD 7648; DNA-PK inhibitor

CAS Number: 2230820-11-6
Compound CID: 135151360

Product Size

5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AZD-7648, soluble in DMSO and insoluble in ethanol and water, impairs the non-homologous end joining (NHEJ) pathway of DNA repair, thereby sensitizing cancer cells to treatments that induce DNA double-strand breaks. It targets ATM, DNA-PKcs, and PI3Kγ.

Molecular Weight

380.4

Molecular Formula

C₁₈H₂₀N₈O₂

Targets

ATM: 17.93 μM; DNA-PKcs: 91.3 μM; PI3Kγ: 1.37 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 5 mg/mL (13.14 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AZD-7648 can be used to investigate its role as an inhibitor of DNA-dependent protein kinase (DNA-PK) in cancer therapy.