DNA-PK inhibitor Compound 401, Purity ≥98%

Cat. No.: X24-05-ZQ231

DNA-PK inhibitor Compound 401, Purity ≥98%

Synonym: 168425-64-7; Compound 401; 2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one; 2-(Morpholin-4-yl)pyrimido[2,1-a]isoquinolin-4-one; TN9PWB4UM5; DNA-PK inhibitor

  • CAS Number: 168425-64-7
  • Compound CID: 10039361
Product Size
10 mg; 25 mg; 50 mg
Price
Datasheet
MSDS
Properties
Description
Compound 401, soluble in DMSO and insoluble in ethanol and water, impairs the non-homologous end joining (NHEJ) pathway of DNA repair, thereby sensitizing cancer cells to treatments that induce DNA double-strand breaks. It targets DNA-PK and mTOR.
Molecular Weight
281.31
Molecular Formula
C16H15N3O2
Targets
DNA-PK: 0.28 μM; mTOR: 5.3 μM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 7 mg/mL (24.88 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Compound 401 can be used to study its effects on PI3K/Akt/mTOR signaling pathways in cancer cells.
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