DNA-PK inhibitor Compound 401, Purity ≥98%

Synonym: 168425-64-7; Compound 401; 2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one; 2-(Morpholin-4-yl)pyrimido[2,1-a]isoquinolin-4-one; TN9PWB4UM5; DNA-PK inhibitor

CAS Number: 168425-64-7
Compound CID: 10039361

Product Size

10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Compound 401, soluble in DMSO and insoluble in ethanol and water, impairs the non-homologous end joining (NHEJ) pathway of DNA repair, thereby sensitizing cancer cells to treatments that induce DNA double-strand breaks. It targets DNA-PK and mTOR.

Molecular Weight

281.31

Molecular Formula

C₁₆H₁₅N₃O₂

Targets

DNA-PK: 0.28 μM; mTOR: 5.3 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 7 mg/mL (24.88 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Compound 401 can be used to study its effects on PI3K/Akt/mTOR signaling pathways in cancer cells.

Storage

Store at -20ºC.