Properties
Description
KU 0060648, soluble in DMSO and insoluble in ethanol and water, impairs the non-homologous end joining (NHEJ) pathway of DNA repair, thereby sensitizing cancer cells to treatments that induce DNA double-strand breaks. It targets DNA-PK, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ.
Molecular Formula
C33H34N4O4S
Targets
DNA-PK: 8.6 nM; PI3Kα: 4 nM; PI3Kβ: 0.5 nM; PI3Kδ: 0.1 nM; PI3Kγ: 0.594 μM
Solubility
DMSO: 0.39 mg/mL (0.66 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
KU 0060648 is utilized to study its inhibitory effects on DNA-PK and the repair of DNA damage in cancer.
