DNA-PK inhibitor KU 0060648, Purity ≥98%

Synonym: 881375-00-4; KU0060648; KU-0060648; DNA-PK inhibitor

CAS Number: 881375-00-4
Compound CID: 11964036

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

KU 0060648, soluble in DMSO and insoluble in ethanol and water, impairs the non-homologous end joining (NHEJ) pathway of DNA repair, thereby sensitizing cancer cells to treatments that induce DNA double-strand breaks. It targets DNA-PK, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ.

Molecular Weight

582.7

Molecular Formula

C₃₃H₃₄N₄O₄S

Targets

DNA-PK: 8.6 nM; PI3Kα: 4 nM; PI3Kβ: 0.5 nM; PI3Kδ: 0.1 nM; PI3Kγ: 0.594 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 0.39 mg/mL (0.66 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

KU 0060648 is utilized to study its inhibitory effects on DNA-PK and the repair of DNA damage in cancer.