Properties
Description
LTURM34, soluble in DMSO and ethanol and insoluble in water, impairs the non-homologous end joining (NHEJ) pathway of DNA repair, thereby sensitizing cancer cells to treatments that induce DNA double-strand breaks. It targets DNA-PK, PI3Kβ, and PI4Kδ.
Molecular Formula
C24H18N2O3S
Targets
DNA-PK: 34 nM; PI3Kβ: 5.8 nM; PI4Kδ: 8.5 nM
Solubility
DMSO: 81 mg/mL (195.42 mM); Water: Insoluble; Ethanol: 4 mg/mL (9.65 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
LTURM34 can be used to study its selective inhibition of specific signaling pathways involved in cancer progression.
