Properties
Description
LTURM34, soluble in DMSO and ethanol and insoluble in water, impairs the non-homologous end joining (NHEJ) pathway of DNA repair, thereby sensitizing cancer cells to treatments that induce DNA double-strand breaks. It targets DNA-PK, PI3Kβ, and PI4Kδ.
Molecular Formula
C24H18N2O3S
Targets
DNA-PK: 34 nM; PI3Kβ: 5.8 nM; PI4Kδ: 8.5 nM
Solubility
DMSO: 81 mg/mL (195.42 mM); Water: Insoluble; Ethanol: 4 mg/mL (9.65 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
LTURM34 can be used to study its selective inhibition of specific signaling pathways involved in cancer progression.
