Properties
Description
Nedisertib, soluble in DMSO and ethanol and insoluble in water, impairs the non-homologous end joining (NHEJ) pathway of DNA repair, thereby sensitizing cancer cells to treatments that induce DNA double-strand breaks.
Molecular Formula
C24H21ClFN5O3
Solubility
DMSO: 86 mg/mL (178.45 mM); Water: Insoluble; Ethanol: 2 mg/mL (4.15 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Nedisertib is utilized in research to study its inhibition of DNA-PK and PI3K in cancer therapy.
