Properties
Description
NU7026, soluble in DMSO and insoluble in ethanol and water, impairs the non-homologous end joining (NHEJ) pathway of DNA repair, thereby sensitizing cancer cells to treatments that induce DNA double-strand breaks. It targets ATM, ATR, DNA-PK, and PI3K.
Molecular Formula
C17H15NO3
Targets
ATM: >100 μM; ATR: >100 μM; DNA-PK: 0.23 μM; PI3K: 13 μM
Solubility
DMSO: 1 mg/mL (3.55 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
NU7026 can be used to investigate its role as a DNA-PK inhibitor and its impact on cell cycle regulation and cancer cell survival.
