DNA-RNA synthesis inhibitor, 4EGI-1, Purity ≥98%

Synonym: 315706-13-9; 4EGI1; 4EGI 1; (2E-2-[[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]-3-(2-nitrophenyl)propanoic acid

MDL: MFCD02330020
CAS Number: 315706-13-9
Compound CID: 5717952

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

4EGI-1, soluble in DMSO and insoluble in water and ethanol, is an effective DNA damage inhibitor, that has the ability to prevent the pathway of DNA damage by inhibiting DNA-RNA synthesis. It targets the eIF4E/eIF4G.

Molecular Weight

451.28

Molecular Formula

C₁₈H₁₂Cl₂N₄O₄S

Targets

eIF4E/eIF4G: 25 μM (Kd)

Form

Lyophilized powder

Purity

≥98%

Titer

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects

Solubility

In vitro: DMSO: 79 mg/mL (175.06 mM); Water: insoluble; Ethanol: insoluble; In vivo: 5% DMSO + pbs, 3 mg/mL

Stability

In its lyophilized form, the chemical remains stable for 36 months.

Quality Level

Research grade

Applications

4EGI-1 is a DNA damage inhibitor that plays a key role in the initiation of translation in eukaryotic cells.

Storage

Store at -20ºC, and keep desiccated.