Properties
Description
CX-5461, soluble in DMSO and warmed ethanol and insoluble in water, is an effective DNA damage inhibitor, that has the ability to prevent the pathway of DNA damage by inhibiting DNA-RNA synthesis. It targets the A375, HCT-116, MIA PaCa-2, and Pol I-driven transcription of rRNA (HCT-116, A375, MIA PaCa-2 cells).
Molecular Formula
C27H27N7O2S
Targets
A375: 58 nM (ED50); HCT-116: 167 nM (ED50); MIA PaCa-2: 74 nM (ED50); Pol I-driven transcription of rRNA (HCT-116, A375, MIA PaCa-2 cells): 142 nM
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Solubility
In vitro: DMSO: <1 mg/mL; Water: insoluble; DMF (warmed): 3 mg/mL (5.84 mM)
Stability
In its lyophilized form, the chemical remains stable for 36 months.
Quality Level
Research grade
Applications
CX-5461 is a DNA damage inhibitor that can be studied extensively for its potential therapeutic applications in the treatment of cancer, especially after cancer stem cells have been sensitized to chemotherapy.
Storage
Store at -20ºC, and keep desiccated.
