Properties
Description
Gemcitabine HCl, soluble in DMSO and water and insoluble in ethanol, is an effective DNA damage inhibitor, that has the ability to prevent the pathway of DNA damage by inhibiting DNA-RNA synthesis. It targets the DNA synthesis (BxPC3 cells), DNA synthesis (Capan2 cells), DNA synthesis (MIAPaCa2 cells), and DNA synthesis (PANC1 cells).
Molecular Formula
C9H11F2N3O4·HCl
Targets
DNA synthesis (BxPC3 cells): 18 nM; DNA synthesis (Capan2 cells): 12 nM; DNA synthesis (MIAPaCa2 cells): 40 nM; DNA synthesis (PANC1 cells): 50 nM
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Solubility
In vitro: DMSO: insoluble; Water: 18 mg/mL (60.06 mM); Ethanol: insoluble; In vivo: Saline, 18 mg/mL
Applications
Gemcitabine HCl is a DNA damage inhibitor that can be studied extensively for its potential therapeutic applications in the treatment of pancreatic cancer, non-small cell lung cancer, and bladder cancer.
