DNMT inhibitor Lomeguatrib, Purity ≥98%

Synonym: 192441-08-0; O6-(4-bromothenyl)guanine; DNA methyltransferase inhibitor

CAS Number: 192441-08-0
Compound CID: 3025944

Product Size

10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Lomeguatrib, soluble in DMSO and insoluble in ethanol and water, blocks the addition of methyl groups to DNA by methyltransferases, impacting gene expression and genome stability. It targets O6-alkylguanine-DNA-alkyltransferas.

Molecular Weight

326.17

Molecular Formula

C₁₀H₈BrN₅OS

Targets

O6-alkylguanine-DNA-alkyltransferas: 5 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 60 mg/mL (183.95 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Lomeguatrib can be used to inhibit the DNA repair enzyme MGMT, enhancing the efficacy of alkylating agents in cancer therapy.