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DNMT inhibitor Lomeguatrib, Purity ≥98%

Cat. No.: X24-05-ZQ556

DNMT inhibitor Lomeguatrib, Purity ≥98%

Synonym: 192441-08-0; O6-(4-bromothenyl)guanine; DNA methyltransferase inhibitor

  • CAS Number: 192441-08-0
  • Compound CID: 3025944
Product Size
10 mg; 25 mg; 50 mg
Price
Datasheet
MSDS
Properties
Description
Lomeguatrib, soluble in DMSO and insoluble in ethanol and water, blocks the addition of methyl groups to DNA by methyltransferases, impacting gene expression and genome stability. It targets O6-alkylguanine-DNA-alkyltransferas.
Molecular Weight
326.17
Molecular Formula
C10H8BrN5OS
Targets
O6-alkylguanine-DNA-alkyltransferas: 5 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 60 mg/mL (183.95 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Lomeguatrib can be used to inhibit the DNA repair enzyme MGMT, enhancing the efficacy of alkylating agents in cancer therapy.
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