Properties
Description
O6-Benzylguanine, soluble in DMSO and ethanol and insoluble in water, blocks the addition of methyl groups to DNA by methyltransferases, impacting gene expression and genome stability.
Molecular Formula
C12H11N5O
Solubility
DMSO: 41 mg/mL (169.95 mM); Water: Insoluble; Ethanol: 10 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
O6-Benzylguanine can be used to inhibit MGMT, increasing the sensitivity of tumor cells to alkylating chemotherapy drugs.
