Properties
Description
SGI 1027, soluble in DMSO and insoluble in ethanol and water, blocks the addition of methyl groups to DNA by methyltransferases, impacting gene expression and genome stability. It targets DNMT1, DNMT3A, and DNMT3B.
Molecular Formula
C27H23N7O
Targets
DNMT1: 6 μM; DNMT3A: 8 μM; DNMT3B: 7.5 μM
Solubility
DMSO: 85 mg/mL (184.17 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
SGI 1027 can be used to inhibit DNA methyltransferases for epigenetic studies.
