DNMT inhibitor SGI 1027, Purity ≥98%

Synonym: 1020149-73-8; SGI-1027; SGI1027; DNA methyltransferase inhibitor

CAS Number: 1020149-73-8
Compound CID: 24858111

Product Size

10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SGI 1027, soluble in DMSO and insoluble in ethanol and water, blocks the addition of methyl groups to DNA by methyltransferases, impacting gene expression and genome stability. It targets DNMT1, DNMT3A, and DNMT3B.

Molecular Weight

461.52

Molecular Formula

C₂₇H₂₃N₇O

Targets

DNMT1: 6 μM; DNMT3A: 8 μM; DNMT3B: 7.5 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 85 mg/mL (184.17 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

SGI 1027 can be used to inhibit DNA methyltransferases for epigenetic studies.

Storage

Store at -20ºC.