DUB inhibitor P005091, Purity ≥98%

Synonym: 882257-11-6; DUB inhibitor; P5091

MDL: MFCD00123202
CAS Number: 882257-11-6
Compound CID: 2819993

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

P005091, soluble in DMSO and insoluble in ethanol and water, targets and inhibits deubiquitinating enzymes, which play a crucial role in regulating protein degradation and maintaining cellular protein homeostasis. It targets Calpain1, MMP13, Caspase-3, CathepsinD, CathepsinK, EKL, PLA2, UCH-L1, USP15, USP20, and USP21.

Molecular Weight

348.22

Molecular Formula

C₁₂H₇Cl₂NO₃S₂

Targets

Calpain 1: >100 μM (EC₅₀); MMP13: >100 μM (EC₅₀); Caspase-3: >100 μM (EC₅₀); CathepsinD: >100 μM (EC₅₀); CathepsinK: >100 μM (EC₅₀); EKL: >100 μM (EC₅₀); PLA2: >100 μM (EC₅₀); UCH-L1: >100 μM (EC₅₀); USP15: >100 μM (EC₅₀); USP20: >100 μM (EC₅₀); USP21: >100 μM (EC₅₀)

Form

Lyophilized powder

Purity

Solubility

DMSO: 28 mg/mL (80.4 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

P005091 is a DUB inhibitor used to investigate its role in the ubiquitin-proteasome system, focusing on immune and cancer-related applications.