DUB inhibitor PR-619, Purity ≥98%

Synonym: 2645-32-1; DUB inhibitor; PR619; PR 619

MDL: MFCD00830384
CAS Number: 2645-32-1
Compound CID: 2817763

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

MSDS

Properties

Description

PR-619, soluble in DMSO and insoluble in ethanol and water, targets and inhibits deubiquitinating enzymes, which play a crucial role in regulating protein degradation and maintaining cellular protein homeostasis. It targets SENP6core, UCH-L3, Calpain1, CathepsinD, CT-L, DEN1, JOSD2, MMP13, PLA2, Plpro, and Trypsin.

Molecular Weight

223.28

Molecular Formula

C₇H₅N₅S₂

Targets

SENP6core: 2.37 μM (EC₅₀); UCH-L3: 2.95 μM (EC₅₀); Calpain1: >50 μM (EC₅₀); CathepsinD: >50 μM (EC₅₀); CT-L: >50 μM (EC₅₀); DEN1: >50 μM (EC₅₀); JOSD2: >50 μM (EC₅₀); MMP13: >50 μM (EC₅₀); PLA2: >50 μM (EC₅₀); Plpro: >50 μM (EC₅₀); Trypsin: >50 μM (EC₅₀)

Form

Lyophilized powder

Purity

Solubility

DMSO: 42 mg/mL (188.1 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

PR-619 is a broad-spectrum DUB inhibitor utilized for its role in exploring protein deubiquitination and its implications in cellular pathophysiology.