Properties
Description
AZ191, soluble in DMSO and ethanol and insoluble in water, is designed to block the activity of dual-specificity tyrosine-regulated kinase (DYRK), which are involved in various cellular processes including cell differentiation and survival. It targets DYRK1A, Dyrk1B, and DYRK2.
Molecular Formula
C24H27N7O
Targets
DYRK1A: 88 nM; Dyrk1B: 17 nM; DYRK2: 1890 nM
Solubility
DMSO: 81 mg/mL (188.58 mM); Water: Insoluble; Ethanol: 1 mg/mL (2.32 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
AZ191 can be used to inhibit KRAS interactions specifically, investigated in cancer progression.
