Properties
Description
AZ191, soluble in DMSO and ethanol and insoluble in water, is designed to block the activity of dual-specificity tyrosine-regulated kinase (DYRK), which are involved in various cellular processes including cell differentiation and survival. It targets DYRK1A, Dyrk1B, and DYRK2.
Molecular Formula
C24H27N7O
Targets
DYRK1A: 88 nM; Dyrk1B: 17 nM; DYRK2: 1890 nM
Solubility
DMSO: 81 mg/mL (188.58 mM); Water: Insoluble; Ethanol: 1 mg/mL (2.32 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
AZ191 can be used to inhibit KRAS interactions specifically, investigated in cancer progression.
