Properties
Description
TAME, soluble in DMSO, water and ethanol, modulates the activity of E3 ubiquitin ligases, which play a critical role in targeting specific proteins for ubiquitination and subsequent degradation by the proteasome. It targets APC.
Molecular Formula
C14H22N4O4S
Solubility
DMSO: 68 mg/mL (198.59 mM); Water: 68 mg/mL (198.59 mM); Ethanol: 3 mg/mL (8.76 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
TAME is an E3 ligase inhibitor used for investigating the degradation of cyclin-dependent kinase inhibitors, relevant in cancer research.
