EGFR-HER2 inhibitor AEE788, Purity ≥98%

Synonym: 497839-62-0; AEE788; AEE-788; AEE 788; NVP-AEE788; (R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; EGFR-HER2 inhibitor

MDL: MFCD11100351
CAS Number: 497839-62-0
Compound CID: 10297043

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AEE788, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets c-Abl, HER2/ErbB2, c-Fms, and c-Kit.

Molecular Weight

440.6

Molecular Formula

C₂₇H₃₂N₆

Targets

c-Abl: 52 nM; HER2/ErbB2: 6 nM; c-Fms: 60 nM; c-Kit: 790 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 81 mg/mL (183.84 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AEE788 can be used to inhibit EGFR and VEGFR, useful in cancer therapeutics research.