EGFR-HER2 inhibitor AEE788, Purity ≥98%

Synonym: 497839-62-0; AEE788; AEE-788; AEE 788; NVP-AEE788; (R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; EGFR-HER2 inhibitor

MDL: MFCD11100351
CAS Number: 497839-62-0
Compound CID: 10297043

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AEE788, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets c-Abl, HER2/ErbB2, c-Fms, and c-Kit.

Molecular Weight

440.6

Molecular Formula

C₂₇H₃₂N₆

Targets

c-Abl: 52 nM; HER2/ErbB2: 6 nM; c-Fms: 60 nM; c-Kit: 790 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 81 mg/mL (183.84 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

AEE788 can be used to inhibit EGFR and VEGFR, useful in cancer therapeutics research.

Storage

Store at -20ºC.