EGFR-HER2 inhibitor Afatinib dimaleate, Purity ≥98%

Synonym: 850140-73-7; BIBW 2992MA2; BIBW-2992; BIBW2992; BIBW 2992; Afatinib; EGFR-HER2 inhibitor

CAS Number: 850140-73-7
Compound CID: 15606394

Product Size

25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Afatinib dimaleate, soluble in DMSO and insoluble in ethanol and water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR (L858R), EGFR (L858R/T790M), EGFR (wt), and HER2.

Molecular Weight

718.08

Molecular Formula

C₃₂H₃₃ClFN₅O₁₁

Targets

EGFR (L858R): 0.4 nM; EGFR (L858R/T790M): 10 nM; EGFR (wt): 0.5 nM; HER2: 14 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 87 mg/mL (121.3 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Afatinib dimaleate is used for its irreversible inhibition of the ErbB family of receptors in studies on various cancers.