EGFR-HER2 inhibitor Afatinib, Purity ≥98%

Synonym: 850140-72-6; BIBW 2992; BIBW-2992; BIBW2992; EGFR-HER2 inhibitor

CAS Number: 850140-72-6
Compound CID: 10184653

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Afatinib, soluble in DMSO and ethanol and insoluble in water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR, EGFR (L858R), EGFR(L858R/T790M), and HER2.

Molecular Weight

485.94

Molecular Formula

C₂₄H₂₅ClFN₅O₃

Targets

EGFR: 0.5 nM; EGFR (L858R): 0.4 nM; EGFR(L858R/T790M): 10 nM; HER2: 14 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 90 mg/mL (185.21 mM); Water: Insoluble; Ethanol: 14 mg/mL (28.8 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Afatinib can be used to investigate its role as an irreversible inhibitor of EGFR and HER2 in cancer therapy.