EGFR-HER2 inhibitor AG-1478, Purity ≥98%

Synonym: 153436-53-4; AG-1478; N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine; Tyrphostin AG 1478; 175178-82-2; Tyrphostin AG-1478; 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline; EGFR-HER2 inhibitor

MDL: MFCD00270914
CAS Number: 153436-53-4
Compound CID: 2051

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AG-1478, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, HER2, and PDGFR.

Molecular Weight

315.8

Molecular Formula

C₁₆H₁₄ClN₃O₂

Targets

EGFR: 3 nM; HER2: >100 μM; PDGFR: >100 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 25 mg/mL (79.17 mM); Water: Insoluble; Ethanol: 13 mg/mL (41.17 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

AG-1478 can be used to inhibit EGFR tyrosine kinase in cancer research.

Storage

Store at -20ºC.