EGFR-HER2 inhibitor AG-17, Purity ≥98%

Synonym: Malonoben; Tyrphostin A9; 10537-47-0; Tyrphostin 9; 2-(3,5-Di-tert-butyl-4-hydroxybenzylidene)malononitrile; EGFR-HER2 inhibitor

MDL: MFCD00209853
CAS Number: 10537-47-0
Compound CID: 5614

Product Size

50 mg; 100 mg; 200 mg; 500 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AG-17, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR and PDGFR.

Molecular Weight

282.4

Molecular Formula

C₁₈H₂₂N₂O

Targets

EGFR: 460 μM; PDGFR: 0.5 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 51 mg/mL (180.6 mM); Water: Insoluble; Ethanol: 51 mg/mL (180.6 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

AG-17 can be used to study its effects as a tyrosine kinase inhibitor in cell signaling research.

Storage

Store at -20ºC.