EGFR-HER2 inhibitor AG-18, Purity ≥98%

Synonym: 118409-57-7; RG-50810; RG-50858; TX 825; Tyrphostin 23; Tyrphostin A23; Tyrphostin AG-18; EGFR-HER2 inhibitor

CAS Number: 118409-57-7
Compound CID: 2052

Product Size

25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AG-18, soluble in DMSO and ethanol and insoluble in water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR.

Molecular Weight

186.17

Molecular Formula

C₁₀H₆N₂O₂

Targets

EGFR: 35 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 34 mg/mL (182.63 mM); Water: Insoluble; Ethanol: 34 mg/mL (182.63 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

AG-18 can be used to study its effects as an inhibitor of FGFR1 tyrosine kinase in cancer and angiogenesis research.

Storage

Store at -20ºC.