EGFR-HER2 inhibitor AG-490, Purity ≥98%

Synonym: 133550-30-8; AG-490; Tyrphostin B42; AG 490; Tyrphostin AG 490; (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide; EGFR-HER2 inhibitor

MDL: MFCD00236452
CAS Number: 133550-30-8
Compound CID: 5328779

Product Size

10 mg; 25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AG-490, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, ErbB2, and JAK2.

Molecular Weight

294.3

Molecular Formula

C₁₇H₁₄N₂O₃

Targets

EGFR: 0.1 μM; ErbB2: 13.5 μM; JAK2: 10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 54 mg/mL (183.48 mM); Water: Insoluble; Ethanol: 6 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

AG-490 can be employed to study JAK2 inhibition and its role in preventing cytokine signaling in cancer and inflammatory diseases.