EGFR-HER2 inhibitor AG-494, Purity ≥98%

Synonym: 133550-35-3; Tyrphostin AG-494; AG494; AG 494; EGFR-HER2 inhibitor

CAS Number: 133550-35-3
Compound CID: 5328771

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AG-494, soluble in DMSO and ethanol and insoluble in water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR.

Molecular Weight

280.28

Molecular Formula

C₁₆H₁₂N₂O₃

Targets

EGFR: 0.7 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 50 mg/mL (178.39 mM); Water: Insoluble; Ethanol: 4 mg/mL (14.27 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

AG-494 can be used to study the inhibition of EGFR tyrosine kinase in cellular signaling pathways.