EGFR-HER2 inhibitor ARRY-380, Purity ≥98%

Synonym: 937263-43-9; Tucatinib; ONT-380; Irbinitinib; EGFR-HER2 inhibitor

CAS Number: 937263-43-9
Compound CID: 51039094

Product Size

5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ARRY-380, soluble in DMSO and ethanol and insoluble in water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets HER2.

Molecular Weight

480.52

Molecular Formula

C₂₆H₂₄N₈O₂

Targets

HER2

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 87 mg/mL (181.05 mM); Water: Insoluble; Ethanol: 14 mg/mL (29.13 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

ARRY-380 can be used to study its effects as a selective HER2 inhibitor in cancer therapy.