Properties
Description
ASP8273, soluble in warmed DMSO and warmed ethanol and insoluble in water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR, EGFR (Exon 19 deletion/T790M), EGFR(L858R), and EGFR(L858R/T790M).
Molecular Formula
C30H42N8O3
Targets
EGFR: 230 nM; EGFR (Exon 19 deletion/T790M); EGFR(L858R); EGFR(L858R/T790M)
Solubility
Warmed DMSO: 50 mg/mL (88.85 mM); Water: Insoluble; Warmed ethanol: 96 mg/mL (170.6 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
ASP8273 can be used to study its irreversible inhibition of EGFR mutants, particularly in lung cancer models.
