EGFR-HER2 inhibitor AST-1306, Purity ≥98%

Synonym: AST-1306; Allitinib; 897383-62-9; AST1306; AST 1306; N-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide; EGFR-HER2 inhibitor

CAS Number: 897383-62-9
Compound CID: 24739943

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AST-1306 is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, EGFR (L858R/T790M), ErbB2, and ErbB4.

Molecular Weight

448.9

Molecular Formula

C₂₄H₁₈ClFN₄O₂

Targets

EGFR: 0.5 nM; EGFR (L858R/T790M): 12 nM; ErbB2: 3 nM; ErbB4: 0.8 nM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

AST-1306 can be used as an irreversible inhibitor of EGFR for research into cancer therapy.