EGFR-HER2 inhibitor AST-6, Purity ≥98%

Synonym: 1050500-29-2; Allitinib tosylate; AST-1306 TsOH; AST-6; AST-1306 (TsOH); N-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]prop-2-enamide; 4-methylbenzenesulfonic acid; EGFR-HER2 inhibitor

CAS Number: 1050500-29-2
Compound CID: 25027665

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AST-6, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets ErbB2, ErbB4, Abl, and Akt1.

Molecular Weight

621.1

Molecular Formula

C₂₄H₁₈ClFN₄O₂.C₇H₈O₃S

Targets

ErbB2: 3.0 nM; ErbB4: 0.8 nM; Abl: >10 μM; Akt1: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 115 mg/mL (185.16 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

AST-6 can be used to inhibit receptor tyrosine kinases, aiding in cancer research.

Storage

Store at -20ºC.