EGFR-HER2 inhibitor AV-412, Purity ≥98%

Synonym: AV-412; 451493-31-5; AV-412 Tosylate; MP-412; AV412; 451493-31-5 (tosylate); EGFR-HER2 inhibitor

CAS Number: 451493-31-5
Compound CID: 11700696

Product Size

2 mg; 5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AV-412 is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, EGFR (L858R), EGFR (L858R/T790M), and EGFR(T790M).

Molecular Weight

851.4

Molecular Formula

C₂₇H₂₈ClFN₆O.2C₇H₈O₃S

Targets

EGFR: 0.75 nM; EGFR (L858R): 0.5 nM; EGFR (L858R/T790M): 2.3 nM; EGFR (T790M): 0.79 nM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

AV-412 can be used to inhibit EGFR and HER2 for research into cancer therapy.