EGFR-HER2 inhibitor AV412, Purity ≥98%

Synonym: 451492-95-8; AV-412 free base; AV-412 (free base); MP-412 free base; N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide; MP-412; N-[4-(3-Chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide; EGFR-HER2 inhibitor

MDL: MFCD16038939
CAS Number: 451492-95-8
Compound CID: 9806229

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AV412 is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, EGFR (L858R), EGFR (L858R/T790M), EGFR (T790M), and ErbB2.

Molecular Weight

507.02

Molecular Formula

C₂₇H₂₈ClFN₆O

Targets

EGFR: 0.75 nM; EGFR (L858R): 0.5 nM; EGFR (L858R/T790M): 2.3 nM; EGFR (T790M): 0.79 nM; ErbB2: 19 nM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

AV412 is primarily used to investigate the inhibition of EGFR-mediated signaling pathways in cancer research.