EGFR-HER2 inhibitor AZ5104, Purity ≥98%

Synonym: 1421373-98-9; AZ-5104; AZ 5104; EGFR-HER2 inhibitor

CAS Number: 1421373-98-9
Compound CID: 71496460

Product Size

10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AZ5104, soluble in DMSO and warmed ethanol and insoluble in water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR (L858R), EGFR (L861Q), ACK1, and ALK.

Molecular Weight

485.58

Molecular Formula

C₂₇H₃₁N₇O₂

Targets

EGFR (L858R): 6 nM; EGFR (L861Q): 1 nM; ACK1: 27 nM; ALK: 97 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 90 mg/mL (185.34 mM); Water: Insoluble; Warmed ethanol: 21 mg/mL (43.24 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

AZ5104 can be used to understand its activity as an EGFR inhibitor in cancer research.