Properties
Description
AZ5104, soluble in DMSO and warmed ethanol and insoluble in water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR (L858R), EGFR (L861Q), ACK1, and ALK.
Molecular Formula
C27H31N7O2
Targets
EGFR (L858R): 6 nM; EGFR (L861Q): 1 nM; ACK1: 27 nM; ALK: 97 nM
Solubility
DMSO: 90 mg/mL (185.34 mM); Water: Insoluble; Warmed ethanol: 21 mg/mL (43.24 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
AZ5104 can be used to understand its activity as an EGFR inhibitor in cancer research.
