Properties
Description
AZD-9291, soluble in warmed DMSO and warmed ethanol and insoluble in water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets Exon 19 deletion EGFR (LoVo cells), L858R/T790M EGFR (LoVo cells), and WT EGFR (LoVo cells).
Molecular Formula
C28H33N7O2
Targets
Exon 19 deletion EGFR (LoVo cells): 12.92 nM; L858R/T790M EGFR (LoVo cells): 11.44 nM; WT EGFR (LoVo cells): 493.8 nM
Solubility
Warmed DMSO: 90 mg/mL (180.14 mM); Water: Insoluble; Warmed ethanol: 39 mg/mL (78.05 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
AZD-9291 can be used to study its effects as a third-generation irreversible EGFR inhibitor targeting EGFR mutations in lung cancer.
