Properties
Description
AZD3759, soluble in DMSO and warmed ethanol and insoluble in water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR (exon 19Del), EGFR (L858R), and EGFR (WT).
Molecular Formula
C22H23ClFN5O3
Targets
EGFR (exon 19Del): 0.2 nM; EGFR (L858R): 0.2 nM; EGFR (WT): 0.3 nM
Solubility
DMSO: 80 mg/mL (173.94 mM); Water: Insoluble; Warmed ethanol: 18 mg/mL (39.13 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
AZD3759 is investigated for its selective inhibition of EGFR and its implications in treating brain metastases from non-small cell lung cancer.
