EGFR-HER2 inhibitor AZD8931, Purity ≥98%

Synonym: Sapitinib; 848942-61-0; AZD8931; AZD-8931; AZD8931 (Sapitinib); 2-(4-((4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-N-methylacetamide; EGFR-HER2 inhibitor

MDL: MFCD18385011
CAS Number: 848942-61-0
Compound CID: 11488320

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AZD8931, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, ErbB2, and ErbB3.

Molecular Weight

473.9

Molecular Formula

C₂₃H₂₅ClFN₅O₃

Targets

EGFR: 4 nM; ErbB2: 3 nM; ErbB3: 4 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 37 mg/mL (78.07 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

AZD8931 is studied for its inhibitory effects on EGFR and HER2 signaling in cancer models.

Storage

Store at -20ºC.