EGFR-HER2 inhibitor AZD8931, Purity ≥98%

Synonym: Sapitinib; 848942-61-0; AZD8931; AZD-8931; AZD8931 (Sapitinib); 2-(4-((4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-N-methylacetamide; EGFR-HER2 inhibitor

MDL: MFCD18385011
CAS Number: 848942-61-0
Compound CID: 11488320

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AZD8931, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, ErbB2, and ErbB3.

Molecular Weight

473.9

Molecular Formula

C₂₃H₂₅ClFN₅O₃

Targets

EGFR: 4 nM; ErbB2: 3 nM; ErbB3: 4 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 37 mg/mL (78.07 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AZD8931 is studied for its inhibitory effects on EGFR and HER2 signaling in cancer models.